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神经性和粘液水肿性克汀病是人类严重缺碘的两种临床表现形式。神经性克汀病在南美Andean地区和亚洲部分地区较常见,粘液水肿性克汀病多发生在中非地区。调查者证实,硒和碘同时缺乏可导致粘液水肿性克汀病。在地方性甲状腺肿高发区扎伊尔北部抽取52名学龄儿童(9～18岁)和26名克汀病患者(3～25岁)作为研究对象,每人每天补充50微克硒蛋氨酸,连续2个月后,正常儿童及克汀病患者血清硒水平和血液中谷胱甘肽过氧化物酶的活性恢复至正常。但在甲状
Neurological and myxedema cretinism are two clinical manifestations of severe iodine deficiency in humans. Neurological cretinism in Andean area of South America and parts of Asia more common, mucoid edema cretinism occurred in Central Africa. Investigators confirmed that both selenium and iodine deficiency can cause mucocutaneous cretinism. Fifty-two school-age children (aged 9-18) and 26 patients with cretinism (aged 3-25) were enrolled in the northern part of Zaire, a high prevalence of endemic goitre. Fifty micrograms of selenomethionine was supplemented daily for 2 consecutive days After a few months, serum selenium level and glutathione peroxidase activity in normal children and cretinism returned to normal. But in the thyroid