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以小鼠强制游泳试验(FST)探讨了加味逍遥散的抗抑郁样作用,并在检测脑内单胺类的同时,进行大脑皮质及海马GABAA受体结合试验。方法:①实验动物为5周龄ddY系雄性小鼠,单剂量或连续经口给予加味逍遥散的冷冻干燥提取物(100、200和400mg/kg)。②FST:将小鼠放入装有1.5L水的2L烧杯
The anti-depressant-like effects of Jiawei Xiaoyao Powder were investigated by the forced swimming test (FST) in mice. GABAA receptor binding assays in the cerebral cortex and hippocampus were performed simultaneously with the detection of monoamines in the brain. METHODS: 1 The experimental animals were 5-week-old ddY male mice. Single-dose or continuous oral freeze-dried extracts (100, 200 and 400 mg/kg) of flavored Xiaoyao San were given orally. 2FST: Place the mouse in a 2L beaker with 1.5L of water