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目的 观察奥美拉唑（ 洛赛克）促进溃疡愈合的机制。方法 （１） 采用胃溃疡胃瘘管的大鼠用中和或比色方法测定胃酸，胃蛋白酶，氨基己糖，用放免或荧光法测定血液和胃液内的胃泌素和组织胺。（２） 用氢气廓氢法测量胃粘膜血流量。（３） 在微需氧条件下培养幽门螺杆菌（Ｈｐ）。结果 洛赛克抑制胃酸，胃蛋白酶的分泌。（２） 增加氨基己糖的浓度和胃粘膜血流量。（３） 洛赛克抑制Ｈｐ 的生长。结论 洛赛克促进溃疡愈合的机制是抑制攻击因子，增加保护因素，抑制Ｈｐ。
Objective To observe the mechanism of omeprazole (Losec) promoting ulcer healing. Methods (1) Gastric acid, pepsin, and hexose hexose were determined by neutralization or colorimetric method in rats with gastric ulcer and gastric fistula. Gastrin and histamine in blood and gastric juice were determined by radioimmunoassay or fluorescence method. (2) Hydrogen peroxide method to measure gastric mucosal blood flow. (3) Helicobacter pylori (Hp) is cultured under microaerobic conditions. Results Losec inhibits gastric acid and pepsin secretion. (2) increase the concentration of hexosamine and gastric mucosal blood flow. (3) Losec inhibits the growth of Hp. Conclusion Losec’s mechanism of promoting ulcer healing is to suppress the attack factor, increase the protective factors and inhibit Hp.