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目的 :评估伽玛刀治疗原发性中枢神经系统淋巴瘤 (PCNSL)的疗效及探讨对其治疗方案的选择。方法 :3 6例经立体定向穿刺活检或手术病理证实为PCNSL的患者采用伽玛刀治疗 ,并对其临床资料、影像特征、治疗方法和随访结果作一回顾性分析。结果 :3 4例术后 1～ 3周临床症状均明显改善。肿瘤完全缓解 (CR) 3 0例 (83 3 %) ,部分缓解 (PR) 6例 (16 6%) ,卡氏评分迅速由术前的平均 5 0 %上升为平均 80 %,局部控制率为 10 0 %。结论 :伽玛刀是综合治疗本病的安全、有效方法之一 ,立体定向穿刺活检是作为本病的重要诊断方法
Objective: To evaluate the efficacy of Gamma Knife in the treatment of primary central nervous system lymphoma (PCNSL) and to explore its treatment options. Methods: Thirty - six patients with PCNSL confirmed by stereotactic biopsy or surgical pathology were treated with gamma knife. The clinical data, imaging features, treatment methods and follow - up results were retrospectively analyzed. Results: The clinical symptoms of 34 cases were significantly improved 1 to 3 weeks after operation. There were 30 patients (83.3%) with complete remission (CR) and 6 (16.6%) patients with partial remission (PR). The Karnofsky score increased rapidly from an average of 50% before surgery to 80% on average. The local control rate was 10 0%. Conclusion: Gamma knife is a safe and effective method for the comprehensive treatment of this disease. Stereotactic biopsy is an important diagnostic method for this disease