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目的探讨深圳市乙肝患者不同感染模式与免疫球蛋白(Ig G、Ig A、Ig M)和补体(C3、C4)的关系。方法采用ELISA技术检测深圳市315例乙肝患者的病毒标志物,按检测结果大三阳、小三阳、小二阳以及乙肝病毒外膜大蛋白结果进行分组。对乙肝患者不同感染模式分别同时进行免疫球蛋白和补体检测,分析乙肝患者的不同感染模式与免疫状况的相关性。结果大三阳与对照组相比,Ig A、Ig G和Ig M增高(U=14.05,9.31,9.15,P<0.01),且C3和C4降低(U=8.22,5.14,P<0.01),差异均有显著统计学意义;小三阳与小二阳之间的比较,3种免疫球蛋白和2种补体的改变(U=1.36,0.34,0.22,0.05,0.06,P>0.05),差异均无统计学意义;小三阳与大三阳之间比较,Ig A、Ig G和Ig M增高(U=5.27,4.35,5.09,P<0.01),C3和C4降低(U=3.68,3.92,P<0.01),差异均具有显著统计学意义;小二阳与大三阳之间比较,Ig A和Ig G增高有统计学意义(U=1.97,2.51,P<0.05)。结论乙肝患者感染模式越严重越容易出现免疫球蛋白的增高而补体的降低。在肝炎的抗病毒治疗中,要治理尽量使HBe Ag转阴,降低对机体免疫系统的损害。
Objective To investigate the relationship between different infection patterns and immunoglobulin (Ig G, Ig A, Ig M) and complement (C3, C4) in patients with hepatitis B in Shenzhen. Methods The viral markers of 315 patients with hepatitis B in Shenzhen were detected by ELISA. The results of three positives, three positives, two positives and hepatitis B virus outer membrane protein were grouped according to the results of the detection. Immunoglobulin and complement were detected simultaneously in different modes of infection in patients with hepatitis B, and the correlation between different infection modes and immune status in hepatitis B patients was analyzed. Results The scores of IgA, IgG and IgM in three groups were significantly higher than those in the control group (U = 14.05,9.31,9.15, P <0.01), and C3 and C4 decreased (U = 8.22,5.14, P <0.01) (P <0.05). The difference was significant (P <0.05). There was significant difference between Xiaosanyang and Xiaonianyang, the changes of three kinds of immunoglobulin and two kinds of complement (U = 1.36,0.34,0.22,0.05,0.06, P> 0.05) There was no significant difference between the three positives and the three positives. The levels of Ig A, Ig G and Ig M were increased (U = 5.27,4.35,5.09, P <0.01), C3 and C4 were lower (U = 3.68,3.92, P <0.01). The differences were statistically significant. The IgA and Ig G increased significantly between Xiaoyang and Daisanyang (U = 1.97,2.51, P <0.05). Conclusion The more serious the infection pattern of hepatitis B patients, immunoglobulin is more likely to appear increased complement and decreased. In the antiviral treatment of hepatitis, we must try to make HBeAg negative, reduce the damage to the body’s immune system.