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目的探讨有丝分裂原激活蛋白激酶p38、癌基因C-erbB-2和雌激素受体(ER)、孕激素受体(PR)在乳腺癌中的表达情况及临床意义。方法采用S-P免疫组化方法对65例乳腺癌组织进行p38、C-erbB-2和ER、PR表达的联合检测。结果乳腺癌组织中p38过阳性表达率为36.9%;正常乳腺组织不表达p38;淋巴结转移患者p38蛋白的过阳性表达率明显高于淋巴结阴性患者;p38的表达与C-erbB-2表达具有相对的一致性,p38的阳性高表达伴随ER表达降低,但与PR的表达无显著相关性。结论p38的过表达与乳腺癌的发生、发展相关。p38与C-erbB-2和ER、PR的联合检测有利于指导乳腺癌的化疗和判断预后。
Objective To investigate the expression and clinical significance of mitogen - activated protein kinase (p38), oncogene C - erbB - 2 and estrogen receptor (ER) and progesterone receptor (PR) in breast cancer. Methods S-P immunohistochemistry was used to detect the expression of p38, C-erbB-2, ER and PR in 65 cases of breast cancer. Results The positive rate of p38 expression in breast cancer was 36.9%, while the normal breast tissue did not express p38. The positive rate of p38 protein expression in lymph node metastasis was significantly higher than that in lymph node-negative patients. The expression of p38 was correlated with the expression of C-erbB-2 The positive expression of p38 was associated with the decrease of ER expression, but not with the expression of PR. Conclusion The overexpression of p38 is associated with the occurrence and development of breast cancer. The combined detection of p38, C-erbB-2, ER and PR can be used to guide the chemotherapy and prognosis of breast cancer.