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目的应用辛伐他汀治疗冠心病并高血脂,探讨其疗效及安全性。方法选择我院符合WHO诊断标准的冠心病并高脂血症患者60例,均符合:①高脂血症;②无肝肾疾病、内分泌疾病;③2周内未用过调脂药物。方法:给予辛伐他汀10mg/d,顿服,连续8周为一疗程。结果治疗8周后 TG、TC和LDL-C较治疗前显著下降(P<0.01)。结论辛伐他汀治疗冠心病并高脂血症疗效明显,无明显不良反应,降血脂持续平稳,适合长期应用,可降低动脉硬化为主要病因的冠心病的发病率及病死率。
Objective To investigate the efficacy and safety of simvastatin in the treatment of coronary heart disease and hyperlipidemia. Methods Sixty patients with coronary heart disease and hyperlipidemia were selected according to WHO diagnostic criteria in our hospital. All were in line with: ① hyperlipidemia; ② no hepatorenal disease, endocrine disease; ③ no lipid-lowering drugs were used in 2 weeks. Methods: Simvastatin 10mg / d, Dayton, for 8 weeks for a course of treatment. Results After 8 weeks of treatment, TG, TC and LDL-C decreased significantly (P <0.01). Conclusion Simvastatin treatment of coronary heart disease with hyperlipidemia obvious effect, no obvious adverse reactions, sustained and stable lipid-lowering, suitable for long-term use, can reduce the incidence of atherosclerosis as the main cause of coronary heart disease and mortality.