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常见人乳头瘤病毒(HPV)亚型(包括HPV16)的预防性疫苗的出现给有效预防宫颈癌带来了希望。HPV病毒样颗粒(virus-like particle,VLP)疫苗预防持续性HPV感染的功效已被证实,但其预防作用是否能超过18个月以及对宫颈上皮内瘤样病变(CIN)Ⅱ～Ⅲ的影响尚不明确。
The emergence of preventive vaccines for common human papilloma virus (HPV) subtypes, including HPV16, has given rise to hope for the effective prevention of cervical cancer. The efficacy of HPV-like particle (VLP) vaccine in preventing persistent HPV infection has been demonstrated, but its preventive effect over 18 months and the effect on cervical intraepithelial neoplasia (CIN) Ⅱ ~ Ⅲ still uncertain.