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目的:制备长春西汀纳米结构脂质载体,考察其体外释放规律。方法:选择pH7.4的磷酸盐缓冲液(PBS)作为释放介质,采用透析法测定长春西汀纳米结构脂质载体的体外释放。结果:长春西汀纳米结构脂质载体在24h释放为44%,药物在体外呈现缓释释放,符合Weibull分布。结论:所制备长春西汀纳米结构脂质载体体外缓释效果良好。
OBJECTIVE: To prepare vinpocetine nanostructured lipid carrier and investigate its in vitro release pattern. Methods: The pH7.4 phosphate buffer (PBS) was selected as the release medium and the release of vinpocetine nanostructured lipid carrier in vitro was determined by dialysis method. Results: The vinpocetine nanostructured lipid delivery was 44% released in 24 hours. The drug showed sustained release in vitro, which was consistent with Weibull distribution. Conclusion: The sustained release of vinpocetine nanostructured lipid carrier is good in vitro.