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本文报道了双羟萘酸副品红经口给药治疗动物日本血吸虫病。小白鼠以3000mg/kg/天,28天疗法;家兔以200～600mg/kg/天,14～28天疗法;犬以140.6～281.3mg/kg/天,28天疗法,其减虫率分别为57.6～71.3％、99.2～100％和45.9～69.0％。与双没食子酸锑钠、硝唑咪和呋喃丙胺并用可以减少药物用量、提高疗效和缩短疗程。作者等并就双羟萘酸副品红的药理和毒理若干方面作了初步探讨。
This paper reports the administration of parapangonate orally to treat Japanese schistosomiasis. The mice were treated with 3000mg / kg / day for 28 days. Rabbits were given 200 ~ 600mg / kg / day for 14 ~ 28 days. The dogs were treated with 140.6 ~ 281.3mg / kg / 57.6 to 71.3%, 99.2 to 100% and 45.9 to 69.0%. With anti-sodium gallic acid, nitazoxan and furan propylamine can reduce the amount of drugs to improve efficacy and shorten the course of treatment. The author also made a preliminary discussion on some aspects of pharmacology and toxicology of pamoic acid.