Objective:To study the effect of Xuesaitong soft capsule (血塞软胶囊, XST) on liver fibrosis criteria in patients with post-hepatitis fibrosis. Methods: Sixty-four patients with such fibrosis were randomly divided into the treated group and control group. They were treated with XST and Dahuang Zheter treatment. Results: The levels of serum procollagen Ⅲ, hyaluronic acid, collagen Ⅳ, laminin in the two groups were significantly lower (P＜0.01) than those before treatment. The differences between the two groups were insignificant (P＞0.05). Conclusion: XST could recover liver dysfunction and had anti-liver fibrosis function.