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对辽宁省 195 0～ 1999年流脑的流行特征进行了分析。结果表明A群流脑多糖菌苗的使用 ,打破了我省每间隔 8年一次高峰的规律 ,大大降低了流脑的发病率 ,削平了流脑年龄别发病的第二个高峰 ,使城乡发病率之差逐年缩小 ,季节流行的特点无变化。血清学监测结果表明 ,菌苗使用后 ,人群杀菌抗体阳性率基本保持在 5 0 %以上 ,GMT在 1:2以上 ,虽未达到杀菌抗体临界保护值 ,但流行病学效果显著。带菌调查结果显示 ,健康人群的带菌率无明显变化 ,以B群为主 ,A群带菌率逐年下降 ,且与发病率呈明显正相关
The epidemiological characteristics of meningitis in Liaoning Province from 1995 to 1999 were analyzed. The results showed that the use of Group A meningitis polysaccharide vaccine broke the law of every peak in every 8 years in our province, greatly reduced the incidence of meningitis and smoothed the second peak of meningitis age-related incidence, The rate of decline year by year, no change in the characteristics of the popular season. Serological surveillance results showed that the bactericidal antibody positive rate remained above 50% and the GMT was above 1: 2 after the vaccine was used. Although the bactericidal antibody critical protection value was not reached, the epidemiological effect was remarkable. The results of carrying bacteria showed that there was no significant change in the carrier rate of healthy people, with group B as the mainstay, and the rate of carriage of group A declining year by year, which was positively correlated with the incidence