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目的比较布氏田鼠与BALB/c小鼠焦虑样行为的差异。方法记录布氏田鼠与BALB/c小鼠在高架十字迷宫实验(总路程、开臂时间及次数、闭臂时间及次数)及旷场实验(总路程、边缘区时间及次数、中央区时间及次数)的焦虑样行为数据。结果高架十字迷宫实验中,布氏田鼠所记录的总路程、闭臂时间均极显著高于BALB/c小鼠(P<0.001),在开臂时间百分比[开臂时间/(开臂时间+闭臂时间)]显著低于BALB/c小鼠(P<0.05)。在旷场实验中布氏田鼠总路程、边缘区滞留时间均极显著高于BALB/c小鼠(P<0.001)。结论布氏田鼠具有显著的焦虑行为,为开发新的焦虑症动物模型提供理想的动物资源。
Objective To compare the anxiety-like behaviors of Brandt’s vole (Microtus brandti) and BALB / c mice. Methods The vomit maze test (total distance, time and number of arm opening, arm closing time and number of times) and open field test (total distance, time and number of marginal zone, time in central area and BALB / c mice) Times) anxiety-like behavior data. Results In the elevated plus-maze test, the total distance and arm closing time recorded by Brandt’s vole (Microtus brandti) was significantly higher than that of BALB / c mice (P <0.001). The percentage of arm opening time [arm opening time / Closed arm time)] was significantly lower than BALB / c mice (P <0.05). In the open field experiment, Brandt’s vole (Microtus brandti) total distance and marginal zone residence time were significantly higher than BALB / c mice (P <0.001). Conclusion The Brandt’s vole (Microtus brandti) has significant anxiety behavior and provides an ideal animal resource for the development of new animal models of anxiety.