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目的：评价定量、喷射、手控雾化3种方法吸入溴化异丙托品对COPD患者的疗效。方法：按病情将25例住院患者分为急性发作期组、慢性迁延期组，吸入溴化异丙托品后4h内观察肺通气功能的变化。结果：吸入溴化丙托品后，患者的肺活量（VC）、V50。V25无明显变化；急性期患者FVC％，FEV1％，Vmax％上升值以手控雾化最高，喷射雾化次之，定量雾化最低；慢性迁延期患者FVC％，FEV1％，Vmax％上升值定量雾化与喷射雾化相近，手控雾化明显高于前两者。结论：定量雾化仅适用于慢性迁延期COPD患者，手控雾化和喷射雾化对于急性发作期及慢性迁延期COPD患者均适用，且手控雾化疗效最佳。
OBJECTIVE: To evaluate the curative effect of inhalation of ipratropium bromide in COPD patients by three methods of quantitative, injection and manual atomization. Methods: Twenty-five inpatients were divided into acute exacerbation group and chronic exacerbation group according to the condition. The changes of pulmonary ventilation function were observed within 4 hours after inhalation of ipratropium bromide. RESULTS: The patient’s vital capacity (VC), V50, after inhalation of droperidol. V25 had no significant change. The rising value of FVC%, FEV1%, Vmax% in the acute phase was the highest in the manual atomization, followed by the spray atomization, the lowest in the quantitative atomization. The increase of FVC%, FEV1%, Vmax% Quantitative atomization and spray atomization are similar, manual atomization was significantly higher than the previous two. Conclusion: Quantitative nebulization is only suitable for COPD patients with chronic delaying. Both manual nebulization and spray nebulization are suitable for patients with acute exacerbation and chronic delaying COPD, and the best results are obtained by manual nebulization.