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目的:比较聚醚醚酮（PEEK）与钛网在颅骨修补整形术中临床应用效果。方法:回顾性分析中国医科大学附属盛京医院2015年1月至2019年12月60例因颅骨缺损行颅骨修补整形术患者的临床资料。其中，颅骨修补材料采用PEEK 25例（PEEK组），采用钛网35例（钛网组）。比较两组患者术后6个月并发症发生情况，比较两组患者塑形效果满意度、住院时间和住院费用。结果:两组出血、感染、癫痫、植入物移位、植入物外露、二次手术发生率及住院时间比较差异无统计学意义（n P>0.05）；PEEK组皮下积液发生率、塑形满意度好率和医疗费用明显高于钛网组[28.0%（7/25）比5.7%（2/35）、88.0%（22/25）比62.9%（22/35）和（12.4 ± 1.5）万元比（7.0 ± 2.4）万元]，差异有统计学意义（n P<0.05或0.05). The incidence of subcutaneous fluid, good plastic surgery satisfaction and hospitalization costs in the PEEK group were significantly higher than those in titanium mesh group: 28.0% (7/25) vs. 5.7% (2/35), 88.0% (22/25) vs. 62.9% (22/35) and (12.4 ± 1.5) × 10n 4 yuan vs. (7.0 ± 2.4) × 10n 4 yuan, and there were statistical differences (n P<0.05 or<0.01).n Conclusions:PEEK material is safe and effective in cranioplasty, and the treatment satisfaction is better, but the cost is higher. PEEK can be used as an ideal skull repair material for patients with economic basis.