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目的：观察短暂脑缺血发作（ＴＩＡ）患者血小板颗粒膜糖蛋白ＧＭＰ－１４０，ＧＰ５３的变化及其临床意义。方法：用流式细胞术，以单克隆抗体作分子探针，检测了１５例单纯型ＴＩＡ和１１例梗塞型ＴＩＡ患者血小板ＧＭＰ－１４０，ＧＰ５３的阳性表达率，并与２０名健康人作对照。结果：梗塞型ＴＩＡ组，ＧＭＰ－１４０，ＧＰ５３阳性率显著高于单纯型ＴＩＡ组和健康对照组（Ｐ＜００１～０００５），但后两组比较无显著差异。梗塞型ＴＩＡ组在发生梗塞后，其阳性率较梗塞前进一步升高（Ｐ＜００１）。结论：动态监测ＴＩＡ患者的ＧＭＰ－１４０，ＧＰ５３，有助于预测ＴＩＡ的发展趋势。对血小板活化率较高的ＴＩＡ患者，可视为血栓前状态，应积极给予治疗
Objective: To observe the changes and clinical significance of GMP-140 and GP53 in platelets of patients with transient ischemic attack (TIA). Methods: The positive rate of platelet GMP-140 and GP53 in 15 cases of simple TIA and 11 cases of infarcted TIA was detected by flow cytometry and monoclonal antibody as probe, and compared with 20 healthy controls . Results: The positive rates of GMP-140 and GP53 in infarcted TIA group were significantly higher than those in simple TIA group and healthy control group (P <001 ~ 0005), but there was no significant difference between the two groups. After infarction, the positive rate of infarction TIA group was higher than before infarction (P <001). Conclusion: Dynamic monitoring of GMP-140 and GP53 in patients with TIA is helpful to predict the development trend of TIA. TIA patients with high rate of platelet activation can be considered as prethrombotic state should be actively treated