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以焦脱镁叶绿酸-a甲酯及其12-氧代衍生物为起始原料,利用试剂氧化和空气氧化在周环上构建了不同的含氧官能团,再通过E-环羰基的Wittig和Grignard反应、20-meso-位的亲电取代反应和3-位乙烯基的1,3-偶极环加成等经典反应进行官能团转换,讨论了132-氧代焦脱镁叶绿酸的分子结构、反应位点及其化学选择性,完成了一系列未见报道的叶绿素类二氢卟吩衍生物的合成,其化学结构均经UV、IR、1H NMR及元素分析予以证实.
Using pyropheophorbide-a methyl ester and its 12-oxo derivative as starting materials, different oxygen-containing functional groups were constructed on the pericyclic ring by reagent oxidation and air oxidation, And Grignard reaction, 20-meso-bit electrophilic substitution reaction and the 3-position vinyl 1,3-dipolar cycloaddition and other classical reactions for functional group conversion, discussed 132-oxo-pyropheophorbide acid Molecular structure, reaction sites and their chemical selectivity. A series of previously reported chlorophyll-type chlorin derivatives were synthesized and their chemical structures were confirmed by UV, IR, 1H NMR and elemental analysis.