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自1948年肾上腺皮质激素(下简称激素)在临床广泛应用以来,已成为治疗肾小球疾病的重要药物,如能合理应用,可取得一定疗效,现将有关问题叙述如下:一、机理激素对肾小球疾病具有抗炎及抗免疫作用,而以前者为主。众所周知,肾小球疾病是免疫反应炎性介质损伤所致,激素能连续地作用于炎症过程的各个阶段,使抗原-抗体结合减轻,抑制淋巴细胞致敏,抑制补体结合,稳定溶酶体等,从而起到治疗作用。
Since 1948 adrenocorticotropic hormone (hereinafter referred to as hormone) has been widely used in clinical practice, has become an important drug for the treatment of glomerular diseases, if can be applied reasonably, can achieve a certain effect, the relevant problems are described below: First, the mechanism of hormone Glomerular disease has anti-inflammatory and anti-immune effects, while the former mainly. It is well-known that glomerular diseases are caused by immune response to inflammatory mediators. Hormones can act continuously on all stages of the inflammatory process, reducing antigen-antibody binding, inhibiting lymphocyte sensitization, inhibiting complement fixation, stabilizing lysosomes, and the like , Which play a therapeutic role.