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目的研究系统性红斑狼疮(SLE)的首发症状及临床特点,提高早期确诊率。方法分析山西省大同市第五人民医院3年来系统性红斑狼疮(SLE)住院患者的发病特点。建立2008年9月至2011年9月山西省大同市第五人民医院108例SLE患者临床资料数据库,并且用SPSS13.0软件对数据进行分析。结果入选病例共108例,男女比例1:8.9。首发症状皮肤黏膜损害为最常见(37%),其次肌肉骨骼系统为29%,泌尿生殖系统11%,血液系统9.3%;呼吸系统8.4%,神经精神系统为1.8%。其中,男性患者肌肉骨骼系受累的发生与女性患者比较,差异有统计学意义(P<0.05),而皮肤黏膜损害、泌尿生殖系统损害、血液系统损害等发生率均高于女性,但差异无统计学意义。SLE患者平均SLE-DAI为(19.95±6.12)分,男性组与女性组的SLEDAI差异无统计学意义。结论 SLE患者以年轻女性为主,男女比例1:8.9。皮肤黏膜和肌肉骨骼系统的累及最常见。不同性别具体临床表现及病情活动度与性别关系不大。
Objective To study the initial symptoms and clinical features of systemic lupus erythematosus (SLE) and to improve the early diagnosis rate. Methods The incidence of systemic lupus erythematosus (SLE) inpatients was analyzed in the Fifth People’s Hospital of Datong City, Shanxi Province in three years. To establish the database of clinical data of 108 SLE patients from the Fifth People’s Hospital of Datong City, Shanxi Province from September 2008 to September 2011, and analyze the data by SPSS13.0 software. Results A total of 108 selected cases, male to female ratio of 1: 8.9. The first symptom of mucocutaneous lesions was the most common (37%), followed by the musculoskeletal system of 29%, genitourinary system of 11%, hematological system of 9.3%, respiratory system of 8.4% and neuropsychiatric system of 1.8%. Among them, the incidence of musculoskeletal involvement in male patients was significantly higher than that in female patients (P <0.05), while the incidence of skin and mucous membrane damage, genitourinary system damage and blood system damage were all higher than those in women, but the difference was not significant Statistical significance. The mean SLE-DAI score of SLE patients was (19.95 ± 6.12) points, while there was no significant difference in SLEDAI between male and female subjects. Conclusions SLE patients are mainly young women, the ratio of male to female is 1: 8.9. Involvement of mucocutaneous and musculoskeletal systems is most common. Different gender specific clinical manifestations and disease activity and gender has little to do.