药物性玻璃体后脱离是近年来许多学者关注的问题。玻璃体后脱离 (posteriorvirteousdetachment,PVD)可以改善增殖性糖尿病性视网膜病变、非增殖性糖尿病性视网膜病变、黄斑裂孔等眼底疾病的预后 ,缩短玻璃体切割手术的时间 ,减少手术并发症。目前 ,药物性PVD的临床与实验研究已取得了一定进展。本文对药物性PVD的组织结构基础 ,药物的作用机制 ,临床及实验研究方面的进展作一综述 Pharmacological vitreous detachment is a concern of many scholars in recent years. Posterior vitreous degeneration (PVD) can improve the prognosis of proliferative diabetic retinopathy, non-proliferative diabetic retinopathy, macular hole disease and other retinal diseases, shorten the vitrectomy operation time and reduce the complications. At present, some progresses have been made in the clinical and experimental research of medicinal PVD. This review summarizes the histological basis of drug-based PVD, the mechanism of drug action, and clinical and experimental progress