论文部分内容阅读
选取乙型肝炎后肝硬化失代偿期患者３０例，对血浆内毒素、一氧化氮代谢产物（ＮＯ２－／ＮＯ３－）、前列环素代谢产物（６－ｋｅｔｏ－ＰＧＦ１α）进行测定。结果表明，肝硬化组三者水平均高于正常对照组（Ｐ＜０．０１）；相关性分析三者间均呈正相关；肝硬化组按Ｃｈｉｌｄ－Ｐａｕｇｈ分级后，Ａ、Ｂ、Ｃ三级间血浆内毒素、ＮＯ２－／ＮＯ３－、６－ｋｅｔｏ－ＰＧＦ１α水平均有显著差异，且随着肝功能减退，血浆中上述３种指标的水平逐渐升高。说明血浆一氧化氮、前列环素水平与内毒素水平的升高有关；内毒素、一氧化氮和前列环素在肝硬化的发生与发展中起了十分重要的作用。
Thirty patients with decompensated liver cirrhosis were enrolled in this study. Plasma endotoxin, nitric oxide metabolites (NO2- / NO3-) and prostacyclin metabolites (6-keto-PGF1α) were determined. The results showed that the levels of liver cirrhosis were higher than that of the normal control group (P <0.01), and the correlation analysis showed a positive correlation between them The levels of plasma endotoxin, NO2- / NO3- and 6-keto-PGF1α were significantly different between the two groups. With the decrease of liver function, the levels of these three indexes in plasma increased gradually. Explain the plasma nitric oxide, prostacyclin levels and endotoxin levels increased; endotoxin, nitric oxide and prostacyclin in the occurrence and development of cirrhosis has played a very important role.