论文部分内容阅读
目的:观察糖尿病周围神经病变(DPN)应用木丹颗粒联合依帕司他治疗的临床疗效。方法:选取80例于我院门诊就诊的DPN患者,随机分为观察组和对照组,每组各40例。两组均给予良好控制血糖、控制血压、纠正血脂异常等基础治疗。观察组应用依帕司他口服,同时服用木丹颗粒,对照组仅服用依帕司他,两组均治疗4周后进行疗效比较。观察指标包括临床症状、症状综合积分(TSS)及神经传导速度。结果:与治疗前相比,两组临床症状及TSS评分均有所改善,且观察组改善优于对照组,P<0.05,有显著差异;两组治疗后神经传导速度较治疗前均有提高,且观察组提高更明显,差异有显著性,P<0.05。结论:木丹颗粒联合依帕司他治疗DPN可取得较好的临床疗效。
OBJECTIVE: To observe the clinical effect of dhobin granule combined with epalrestat on diabetic peripheral neuropathy (DPN). Methods: Eighty DPN patients were selected for outpatient clinic in our hospital and randomly divided into observation group and control group, 40 cases in each group. Both groups were given good control of blood glucose, blood pressure control, blood lipid abnormalities and other basic treatment. The observation group was treated with epalrestat orally, while taking clodione granules. The control group was treated with epalrestat only, and the curative effect was compared between the two groups after 4 weeks of treatment. Observations included clinical symptoms, integrated symptom scores (TSS), and nerve conduction velocity. Results: Compared with those before treatment, the clinical symptoms and TSS scores improved in both groups, and the observation group improved better than the control group, P <0.05, there was a significant difference; nerve conduction velocity increased after treatment in both groups , And the observation group increased more significantly, the difference was significant, P <0.05. Conclusion: The combination of Mudan granules and epalrestat in the treatment of DPN can achieve better clinical efficacy.