冷冻治疗肿瘤已有相当长的历史,但以往的治疗多局限于体表或与外界相通的脏器。1963年Cooper提出了冷冻治疗肝癌的设想,1973年上海医科大学肝癌研究所开展了冷冻治疗肝癌的实验和临床研究,近年随着冷冻技术及其设备的迅速发展,冷冻外科(Cryosurgery)在肝癌治疗中已取得了显著的进展,且已成为一门具有许多独特优点的外科治疗新技术日益受到重视和研究。本文就冷冻治疗肝癌有关问题作一综述。 There is a long history of cryotherapy of tumors, but previous treatments are limited to the body or organs that are connected to the outside world. In 1963, Cooper proposed a concept of cryotherapy for liver cancer. In 1973, the Institute of Liver Cancer, Shanghai Medical University conducted an experimental and clinical study of cryotherapy for liver cancer. In recent years, with the rapid development of cryogenic technology and its equipment, cryosurgery has been used in the treatment of liver cancer. It has made remarkable progress, and has become a new surgical technique with many unique advantages has been increasingly valued and studied. This article reviews the issues related to cryotherapy of liver cancer.