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目的探讨曲安奈德鼻喷剂联合孟鲁司特片治疗变应性鼻炎(AR)的临床疗效。方法 90例AR患者分为A组、B组、C组各30例。A组给予曲安奈德鼻喷剂喷鼻,每鼻孔每次2揿(每揿含曲安奈德55μg),1次/d;B组口服孟鲁司特片10mg/次,1次/d;C组患者同时给予曲安奈德鼻喷剂喷鼻和口服孟鲁司特片,疗程均为15d。结果治疗前3组血IL-6、尿LTE4含量相似(P>0.05);治疗后,C组血IL-6、尿LTE4含量降低较A组、B组更明显(均P<0.05)。C组疗效明显优于A组(u=4.19,P<0.05)和B组(u=3.98,P<0.05)。结论联合应用曲安奈德鼻喷剂、孟鲁司特片治疗AR疗效更佳。
Objective To investigate the clinical efficacy of triamcinolone acetonide combined with montelukast tablets in the treatment of allergic rhinitis (AR). Methods 90 cases of AR patients were divided into A group, B group, C group of 30 cases. Group A was given nasal spray of triamcinolone acetonide nasal spray every nostril 2 揿 (each 揿 containing triamcinolone acetonide 55)), once / d; B group oral montelukast tablets 10 mg / time, once / d; Patients in group C received triamcinolone acetonide nasal spray and oral montelukast tablets simultaneously for 15 days. Results The blood levels of IL-6 and urine LTE4 in the three groups before treatment were similar (P> 0.05). After treatment, the levels of IL-6 and LTE4 in serum of group C were significantly lower than those of group A and B (all P <0.05). The efficacy of group C was better than that of group A (u = 4.19, P <0.05) and group B (u = 3.98, P <0.05). Conclusion Combined use of triamcinolone acetonide nasal spray, montelukast tablets in the treatment of AR better.