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目的 :研究附子汤与芍药甘草汤合用的镇痛作用及其机制。方法 :采用福尔马林疼痛模型大鼠 ,观察药物的镇痛作用 ;采用冰醋酸致痛模型小鼠 ,测血清和脊髓中一氧化氮 (NO催化光度法 )、前列腺素E2 (PGE2 )的含量和超氧化物歧化酶 (SOD)活性 (紫外分光光度法 )。结果 :附子汤加芍药甘草汤能抑制福尔马林引起的I相及Ⅱ相疼痛 ,能显著降低冰醋酸疼痛模型小鼠血清中和脊髓中的NO ,PGE2 的含量 ,增加SOD的活性。结论 :附子汤与芍药甘草汤合用对中枢及外周神经末梢均有镇痛作用 ,其镇痛作用与NO ,PGE2 ,SOD有关
Objective : To study the analgesic effect and mechanism of Fuzi decoction combined with peony and licorice decoction. METHODS: Formalin pain model rats were used to observe the analgesic effect of the drug; glacial acetic acid induced pain model mice were used to measure serum and spinal cord nitric oxide (NO catalytic spectrophotometry) and prostaglandin E2 (PGE2) Content and superoxide dismutase (SOD) activity (ultraviolet spectrophotometry). RESULTS: Fuzi Decoction and Shaoyao Gancao Decoction can inhibit formalin-induced phase I and II pain, and can significantly reduce NO and PGE2 levels in the serum and spinal cord of glacial acetic acid pain model mice, and increase SOD activity. Conclusion : Combined use of Fuzi Decoction and Shaoyao Gancao Decoction has an analgesic effect on central and peripheral nerve endings. Its analgesic effect is related to NO, PGE2, and SOD.