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我们在雌激素对宫颈癌细胞系具有放射增敏作用的实验基础上,将尼尔雌醇应用于宫颈癌放射治疗的病人,每月服药一次,每次5mg,并以同时期、同年龄、同期别、同病理类型的宫颈癌放疗病人作为对照。本又结果显示,尼尔雌醇能提高治愈率,具有放射增敏作用,与对照组比较P<0.01。服药组病人的放射反应发生率并不降低,但持续时间较短。我们在尼尔雌醇的应用中偶然发现,尼尔雌醇可用于治疗直肠、小肠等部位的急性放射反应,尤其治疗小肠反应效果甚好。一次服用尼尔雌醇5mg,可治愈大部分小肠反应,减轻大多数直肠反应,尤其是较轻程度的直肠反应。尼尔雌醇还能改善个别病人的精神和食欲。我们的观察显示,将尼尔雌醇合并应用于宫颈癌放射治疗是安全的,并且常可取得良好效果。
We estrogen on cervical cancer cell line with radiosensitization based on the experiment, the application of nilestriol in cervical cancer radiotherapy patients, once a month medication, each 5mg, and with the same period, same age, The same period, the same type of pathological cervical cancer radiotherapy patients as a control. The results showed that nilestriol can improve the cure rate, with radiosensitization, compared with the control group P <0.01. The incidence of radiation reactions in the medication group did not decrease, but the duration was shorter. In the application of nilestriol, we accidentally discovered that nilestriol can be used to treat acute radiation reactions in the rectum, small intestine and other parts, especially for the treatment of small intestine. Taking nylestriol 5mg once can cure most of the small intestine reactions and relieve most rectal reactions, especially mild rectal reactions. Nilestriol can also improve the individual patient’s mental and appetite. Our observations indicate that the combination of nilesinol for cervical cancer is safe and often achieves good results.