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目的:调查长江流域6市样本医院使用磷酸肌酸药物的情况,为临床合理用药提供有益信息。方法:利用上海市食品药品监督管理局科技情报研究所医院用药分析系统提供的2006～2008年长江流域6市185家样本医院磷酸肌酸用药信息,对金额、年增长率及用药频度进行统计分析。结果:6市样本医院3年来磷酸肌酸使用金额逐年快速增长,其中杭州、武汉2008年该品种的排序已进入领先药品的前100位,分列第16位和77位。结论:近3年来,样本医院磷酸肌酸用药金额迅速上升,似有替代三磷腺苷和果糖二磷酸的趋势。而Medline数据库临床报道文献很少,缺乏循证医学证据。磷酸肌酸在国内可能存在不合理应用和过度医疗行为。
Objective: To investigate the use of creatine phosphate drugs in 6 sample hospitals in the Yangtze River basin to provide useful information for clinical rational drug use. Methods: Using the information of phosphocreatine administration in 185 sample hospitals in 6 cities of 6 cities in Yangtze River Valley from 2006 to 2008 provided by the Hospital Drug Analysis System of Institute of Scientific and Technical Information of Shanghai Food and Drug Administration, the amount, annual growth rate and frequency of medication were counted analysis. Results: The amount of creatine phosphate use in the 6 sample hospitals increased rapidly year by year. Among them, the rankings of Hangzhou and Wuhan in 2008 ranked among the top 100 of the leading drugs and ranked 16th and 77th respectively. Conclusion: In the recent 3 years, the amount of phosphocreatine in the sample hospitals increased rapidly, which seems to be the trend of replacing the ATP and fructose diphosphate. However, there are few clinical reports on Medline database and there is a lack of evidence-based medicine. Creatine phosphorate in the country may be inappropriate use and excessive medical practices.