[目的]了解兰州市2008年手足口病流行病学特征,为手足口病防治工作提供科学依据。[方法]运用描述性流行病学方法,对兰州市不同性别、年龄、职业、地区及时间手足口病情况进行了分析。[结果]2008年全市共报告手足口病例3396例,发病率为104.29/10万,其中,男性2152例,女性1244例,男女比例为1.7︰1,病例主要集中在1~5岁年龄组,占发病总数的74.68%;该市病例报告呈现7月和10月两个高峰;人口密集地区发病高于稀疏地区。[结论]养成良好的卫生习惯是手足口病的重要预防措施。 [Objective] To understand the epidemiological characteristics of hand-foot-mouth disease in Lanzhou in 2008 and provide a scientific basis for the prevention and treatment of hand-foot-mouth disease. [Methods] Descriptive epidemiological methods were used to analyze the situation of hand, foot and mouth disease of different sexes, ages, occupations, regions and time in Lanzhou City. [Results] A total of 3396 cases of hand, foot and mouth were reported in the city in 2008, with an incidence rate of 104.29 / 100 000, of which 2152 were male and 1244 were female, the ratio of male to female was 1.7: 1. The cases mainly concentrated in the age group of 1 to 5 years, Accounting for 74.68% of the total incidence; the city case report showed two peaks in July and October; the incidence in densely populated areas was higher than that in sparse areas. [Conclusion] Developing good health habits is an important preventive measure for HFMD.