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BACKGROUND:Pancreatic stellate cells(PSCs)play a critical role in the development of pancreatic fibrosis.In this study we used a novel method to isolate and culture rat PSCs and then investigated the inhibitory effects of adipose-derived stem cells(ADSCs)on activation and proliferation of PSCs.METHODS:Pancreatic tissue was obtained from SpragueDawley rats for PSCs isolation.Transwell cell cultures were
BACKGROUND: Pancreatic stellate cells (PSCs) play a critical role in the development of pancreatic fibrosis. In this study we used a novel method to isolate and culture rat PSCs and then investigated the inhibitory effects of adipose-derived stem cells (ADSCs) on activation and proliferation of PSCs. METHODS: Pancreatic tissue was obtained from Sprague Dawley rats for PSCs isolation. Transwell cell cultures were