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我国是社会主义国家,中期妊娠引产是不提倡的。但由于产妇患有某种疾病或其他原因不适宜继续妊娠,以及避孕失败而采取这种补救措施。本文就中期妊娠引产药物的近况作一概述,供临床使用参考。一、作用机制和应用 (一)天花粉 1.引产原理:天花粉直接作用于胎盘的滋养层细胞,使之变性坏死。滋养层细胞具有担任胎盘的分泌与吸收等重要功能,它的变性坏死可影响胎盘的内分泌功能及胎儿对营养物的吸收,并使胎盘激素的合成受阻。此外,天花粉还能引起蜕膜炎和羊膜炎,也能使内源性前列腺素的分泌增加。已知羊膜—绒毛膜中含有丰富的花生四烯酸,并有水解使其游离的磷酸酯酶A_2。当给予天花粉后。羊膜受到刺
China is a socialist country. Induction of labor in mid-term pregnancy is not advocated. However, this remedy is taken because the mother is ill with a disease or other reasons unsuitable for the continuation of her pregnancy, and her contraception failed. This article on the status of midwifery induction of abortion drugs for an overview for clinical use of reference. First, the mechanism and application of (a) TCS 1. Induced labor principle: TCS directly on the trophoblast cells of the placenta, the degeneration and necrosis. Trophoblast cells play an important role in the secretion and absorption of the placenta, its degeneration and necrosis can affect the endocrine function of the placenta and fetal absorption of nutrients, and the synthesis of placental hormone blocked. In addition, TCS can cause decidua and amniotic inflammation, but also make the secretion of endogenous prostaglandins increased. It is known that the amnion-chorion is rich in arachidonic acid and hydrolyzes its free phosphatase A_2. When given TCS. Amniotic membrane thorn