内皮衍生小分子气体一氧化氮(nitric oxide,NO)因阐明了NO在心血管系统中是具有重要调节作用。随后的研究揭示了NO参与多种病理生理过程,包括血管舒张、神经传递、巨噬细胞街道的细胞毒性、胃肠道平滑肌舒张及支气管扩张~[1]。在生物体内,NO的生成过程需要关键酶一氧化氮合酶(nitric oxide synthase,NOS)的参与,将L-精氨酸(L-arginine,L-Arg)和分子氧作为底物,由还原型烟酰胺腺嘌呤二核苷酸 Endothelial derived small molecule gas nitric oxide (NO) has been elucidated for its important regulatory role in the cardiovascular system. Subsequent studies revealed that NO participates in a variety of pathophysiological processes, including vasodilation, neurotransmission, cytotoxicity in macrophage streets, relaxation of gastrointestinal smooth muscle and bronchiectasis. [1] In vivo, the production of NO requires the participation of the key enzyme nitric oxide synthase (NOS). Using L-arginine (L-arginine) and molecular oxygen as substrates, Prototype nicotinamide adenine dinucleotide