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本文研究了葛根黄豆甙元及其固体分散物对清醒的自发性高血压大鼠血压的影响。口服葛根黄豆甙元固体分散物300mg/kg,2h血压下降达高峰,收缩压下降12.8%,而等量的葛根黄豆甙元及PVP均无明显改变,葛根黄豆甙元固体分散物使自发性高血压大鼠血浆中血管紧张素下降52.4%,使wistar大鼠的PRA下降24.7%.麻醉猫iv.25mg/kg,收缩压下降18.6±10.6%,舒张压下降43.0±19.2%.
This paper studied the effects of Pueraria lobata glucosides and its solid dispersions on blood pressure in conscious spontaneously hypertensive rats. Oral administration of Pueraria lobata Sophora japonica solid dispersion 300mg/kg, 2h blood pressure decreased to a peak, systolic blood pressure decreased 12.8%, while the same amount of Pueraria lobosa bean aglycone and PVP were not significantly changed, Pueraria globosum aglycone solid dispersion made spontaneous high Angiotensin in plasma of rats with blood pressure decreased by 52.4%, which decreased the PRA of Wistar rats by 24.7%. The systolic blood pressure of anaesthetized cats decreased by 18.6±10.6%, and the diastolic blood pressure decreased by 43.0±19.2%.