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结核菌素试验阳性仅表明机体的淋巴细胞曾被结核杆菌致敏,不能区别这是免疫活性还是免疫记忆。测定T 细胞活性则有助于判断宿主的免疫状态和疗效。鉴于抗原活化T 细胞的增殖需要白细胞介素-2(IL-2),而可溶性白细胞介素-2受体(SIL-2R)的增加与分支杆菌抗原引起的免疫活化有关.本文研究结核病及其化疗对SIL-2R 的影响.研究对象为14名正常人,12例肺结核和8例肺外结核患者。这20例结核病患者均诊断明确,并在严格监督下接受正规抗结核治疗。分别于治疗前及治疗后2～3个月内每月采静脉血标本,分离血清后,用酶
Tuberculin test positive only shows that the body’s lymphocytes have been sensitized by Mycobacterium tuberculosis, can not distinguish between immune activity or immune memory. Determination of T cell activity is helpful to determine the host’s immune status and efficacy. In view of the fact that the proliferation of antigen-activated T cells requires interleukin-2 (IL-2), the increase of soluble interleukin-2 receptor (SIL-2R) is related to the immunological activation induced by mycobacterial antigens. Effects of chemotherapy on SIL-2R The subjects were 14 normal subjects, 12 pulmonary tuberculosis patients and 8 pulmonary tuberculosis patients. The 20 cases of tuberculosis patients were diagnosed, and under strict supervision of regular anti-TB treatment. Venous blood samples were taken monthly before treatment and 2 ~ 3 months after treatment. After separation of serum,