对肝、心肌及肾细胞死亡的生化实验研究表明,缺血或中毒引起细胞水平第一个可测定的变化是钙在细胞溶质的堆积,接着出现线粒体改变、细胞肿胀、血管收缩以致细胞死亡。这个过程在线粒体代谢改变发生之前是可逆的,因此,使用异搏定或心痛定等钙离子拮抗剂以减少钙离子通过细胞膜流入细胞内,有可能防止细胞发生不可逆改变。本文把20例脑死亡的 Biochemical experimental studies of liver, cardiac, and renal cell death have shown that the first measurable change in cell level caused by ischemia or poisoning is the accumulation of calcium in the cytosol, followed by mitochondrial changes, cell swelling, and vasoconstriction leading to cell death. This process is reversible before changes in mitochondrial metabolism occur. Therefore, the use of calcium antagonists such as verapamil or nifedipine to reduce the influx of calcium ions into the cell through the cell membrane may prevent irreversible changes in cells. In this paper, 20 cases of brain death