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目的研究微量元素锌在反复呼吸道感染(RRI)患儿中的应用效果。方法收集RRI患儿84例,采用随机平行对照法分为对照组和观察组,各42例。对照组给予常规抗感染、对症等基础治疗,观察组在对照组基础上加用微量元素锌制剂口服,10 ml/次,≤2岁患儿2次/d,>2岁患儿3次/d,均持续治疗2个月,并有效随访6个月。观察两组的退热时间、止咳时间、肺部体征消失时间和住院时间,分别采用免疫散射比浊法和双抗体夹心酶联免疫吸附试验检测治疗前、治疗后3个月血清IgA、IgG、IgM、TNF-α、IL-6的表达水平。记录6个月内上、下呼吸道感染次数。选择SPSS19.0统计软件进行统计学处理。结果观察组退热时间、止咳时间、肺部体征消失时间和住院时间均少于对照组,差异有统计学意义(P均<0.05)。观察组治疗后6个月内上、下呼吸道感染次数明显少于对照组,差异有统计学意义(均P<0.05)。两组治疗后3个月IgA、IgG、IgM水平较本组治疗前升高,TNF-α、IL-6水平降低,以观察组为著(均P<0.05)。对照组不良反应发生率为11.90%,观察组为7.14%,两组比较,χ~2=1.120,P>0.05。结论微量元素锌可升高RRI患儿血清免疫球蛋白,降低TNF-α、IL-6表达水平,抑制炎症损伤,临床治疗从而改善临床症状,减少呼吸道感染次数。
Objective To study the effect of trace element zinc in children with recurrent respiratory tract infection (RRI). Methods Eighty-four children with RRI were collected and randomly divided into control group and observation group with 42 cases in each group. The control group was given conventional anti-infective and symptomatic treatment. The observation group was orally administered with trace element zinc on the basis of the control group. The children in the observation group were treated with 10 ml / d, were treated for 2 months, and effective follow-up of 6 months. Antipyretic time, cough time, disappearance time of lung signs and hospital stay were observed. Immunostaining turbidimetry and double antibody sandwich enzyme-linked immunosorbent assay were used to detect serum IgA, IgG, IgM, TNF-α, IL-6 expression levels. Record the number of upper and lower respiratory tract infections within 6 months. Select SPSS19.0 statistical software for statistical analysis. Results The observation group had less antipyretic time, cough-relieving time, disappearance of lung signs and hospital stay than the control group (P <0.05). The number of upper respiratory tract infection and lower respiratory tract infection in the observation group was significantly less than that in the control group within 6 months after treatment, with significant difference (all P <0.05). The level of IgA, IgG and IgM increased at 3 months after treatment in both groups, and the levels of TNF-α and IL-6 decreased in the observation group (all P <0.05). The incidence of adverse reactions in the control group was 11.90% and in the observation group was 7.14%. There was no significant difference between the two groups (χ ~ 2 = 1.120, P> 0.05). Conclusion Microelement zinc can elevate serum immunoglobulin, reduce the expression of TNF-α and IL-6 in children with RRI, inhibit inflammatory injury and improve the clinical symptoms and reduce the number of respiratory infections.