论文部分内容阅读
目的探讨恶性肿瘤家族史与肺癌发生的关系。方法通过计算机检索PubMed、CENTRAL、中国生物医学文献数据库系统(CBM)、中国期刊全文数据库(CNKI)、中文科技期刊全文数据库(VIP),收集国内外在1988—2009年间公开发表的恶性肿瘤家族史与肺癌关系的病例-对照研究。采用系统评价方法对各研究结果进行分析,计算其合并优势比(OR)和95%可信区间(CI)。结果纳入合并分析的文章共17篇(10490例病例),结果表明,恶性肿瘤家族史与一级亲属肺癌的发生有关(OR=1.58,95%CI:1.31～1.91,P<0.0001)。分层分析表明,一级亲属患恶性肿瘤与非吸烟者肺癌的发生有关(OR=1.46,95%CI:1.08～1.97,P=0.01);一级亲属患肺癌与肺癌的发生有关(OR=1.71,95%CI:1.49～1.95,P<0.0001);一级亲属中父亲、母亲及兄弟姐妹(包括同父异母和同母异父者)患恶性肿瘤与肺癌的发生有关[OR值分别为1.43(95%CI:1.10～1.84,P=0.007)、1.36(95%CI:0.99～1.87,P=0.06)和1.51(95%CI:1.35～1.69,P<0.0001)]。结论恶性肿瘤家族史明显增加一级亲属患肺癌的风险。
Objective To investigate the relationship between the family history of malignant tumor and the occurrence of lung cancer. Methods PubMed, CENTRAL, CBM, CNKI and VIP were searched by computer. The family history of malignant tumors published at home and abroad from 1988 to 2009 was collected. Case-control study of lung cancer. The results of each study were analyzed using systematic reviews and their combined odds ratio (OR) and 95% confidence interval (CI) were calculated. Results A total of 17 articles (10490 cases) were included in the combined analysis. The results showed that the family history of malignant tumors was associated with the occurrence of lung cancer of first degree relatives (OR = 1.58, 95% CI: 1.31-1.91, P <0.0001). Hierarchical analysis showed that the first-degree relatives had a correlation with the incidence of lung cancer in non-smokers (OR = 1.46, 95% CI: 1.08-1.97, P = 0.01); first-degree relatives had lung cancer and lung cancer (OR = 1.71, 95% CI: 1.49-1.95, P <0.0001). The first-degree relatives had a correlation between the incidence of malignant tumors and lung cancer among their father, mother and siblings (including half-and far-sighted) [OR Were 1.43 (95% CI: 1.10-1.84, P = 0.007), 1.36 (95% CI: 0.99-1.87, P = 0.06) and 1.51 (95% CI: 1.35-1.69, P <0.0001). Conclusion The family history of malignant tumors significantly increases the risk of first-degree relatives suffering from lung cancer.