胆道闭锁Kasai术后胆管炎的发病机制探讨

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胆管炎是胆道闭锁Kasai术后的常见并发症,对患儿的生活质量及自肝生存均有较大影响.术中患儿自身肝脏状况会影响术后胆汁引流,Kasai术后胆管炎的发生与胆汁引流状况关系密切.空肠胆支内存在的细菌因肠道环境改变而大量繁殖可能是胆管炎发生的主要原因,远端空肠内容物反流入空肠胆支中也可诱发胆管炎.除了直接逆行感染外,肠道细菌突破肠黏膜经门静脉入肝,也是导致胆管炎发生的原因之一.
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