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目的：采用避孕剂Ｎｏｒｐｌａｎｔ皮下埋植小鼠模型，埋植三个月后，观察Ｎｏｒｐｌａｎｔ对机体免疫功能的影响；方法：实验用３６只小鼠分成６组，每组６只，其中，Ａ、Ｂ、Ｃ三组皮下埋植Ｎｏｒｐｌａｎｔ，Ｄ、Ｅ、Ｆ三组做为对照；Ａ、Ｄ组观察脾脏淋巴细胞对ＣｏｎＡ的增殖反应，Ｂ、Ｅ组观察Ｓ１８０移殖后的瘤重，Ｃ、Ｆ组观察白色念珠菌感染后的存活期；结果：淋巴细胞增殖反应及瘤重与对照组相比无显著差异；白色念珠菌感染后存活期比对照组减少，但统计学处理无显著性差异；结论：本实验结果为临床应用Ｎｏｒｐｌａｎｔ安全性提供了理论依据。
OBJECTIVE: To observe the effects of Norplant on the immune function of mice by implanting Norplant, a contraceptive agent, into mice subcutaneously for 3 months. Methods: 36 mice were divided into 6 groups (6 mice in each group) B, C three groups were subcutaneously implanted Norplant, D, E, F three groups as a control; A, D group spleen lymphocytes to observe the proliferative response of ConA, B, E group observed S180 tumor weight, C, Group F was observed survival of Candida albicans infection; Results: Lymphocyte proliferation and tumor weight compared with the control group no significant difference; Candida albicans infection than the control group, but no statistically significant difference ; Conclusion: The results of this experiment provide a theoretical basis for the clinical application of Norplant safety.