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目的:通过Meta分析方法探讨髓过氧化物酶(MPO)基因与急性白血病[包括急性髓性白血病和急性淋巴细胞白血病(ALL)]及ALL易感性的关系。方法:检索截止2016年3月31日前发表的有关MPO基因位点多态性与急性白血病及ALL易感性关联的病例对照研究的文献,采用Meta分析进行统计分析。结果:共有5篇文献被纳入Meta分析中。对于ALL组,MPO-463基因AA与GG比较:OR=1.36,95%CI=0.74~2.49,P=0.33;AA+GA与GG比较,OR=1.03,95%CI=0.80~1.34,P=0.82;AA与GG+GA比较:OR=1.39,95%CI=0.76~2.53,P=0.29;A与G比较,OR=1.06,95%CI=0.86~1.31,P=0.58;GA与GG比较:OR=1.00,95%CI=0.76~1.30,P=0.97。对于急性白血病组,AA与GG比较,OR=0.83,95%CI=0.36~1.92,P=0.67;AA+GA与GG比较,OR=0.52,95%CI=0.40~0.69,P<0.000 01;AA与GG+GA比较,OR=1.01,95%CI=0.49~2.50,P=0.81;A与G比较,OR=0.64,95%CI=0.51~0.80,P=0.000 1;GA与GG比较,OR=0.51,95%CI=0.39~0.67,P<0.000 01。结论:Meta分析结果表明,MPO-463位点A突变基因可以有意义地降低急性白血病易感性,而目前我们尚无足够的依据证明MPO-463基因能够影响ALL易感性。
Objective: To investigate the relationship between myeloperoxidase (MPO) gene and susceptibility to acute leukemia (including acute myeloid leukemia and acute lymphoblastic leukemia (ALL)) and ALL by Meta analysis. METHODS: The literatures of the case-control study of MPO gene locus polymorphism associated with acute leukemia and ALL susceptibility published before March 31, 2016 were searched. Meta analysis was used for statistical analysis. Results: A total of 5 articles were included in the meta-analysis. For the ALL group, MPO-463 gene AA compared with GG: OR=1.36, 95% CI=0.74~2.49, P=0.33; AA+GA compared with GG, OR=1.03, 95% CI=0.80~1.34, P= 0.82; AA compared with GG+GA: OR=1.39, 95%CI=0.76~2.53, P=0.29; A vs. G, OR=1.06, 95%CI=0.86~1.31, P=0.58; GA vs. GG : OR = 1.00, 95% CI = 0.76 to 1.30, P = 0.97. For acute leukemia group, AA and GG, OR = 0.83, 95% CI = 0.36 ~ 1.92, P = 0.67; AA + GA compared with GG, OR = 0.52, 95% CI = 0.40 ~ 0.69, P <0.00001; Compared with GG+GA, OR, OR=1.01, 95%CI=0.49~2.50, P=0.81; A and G, OR=0.64, 95%CI=0.51~0.80, P=0.0001; GA and GG, OR=0.51, 95% CI=0.39-0.67, P<0.00001. Conclusion: Meta-analysis showed that MPO-463 locus A mutation can significantly reduce acute leukemia susceptibility. At present, we do not have enough evidence to prove that MPO-463 gene can affect ALL susceptibility.