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目的:探讨O型孕妇血清IgG抗A(B)抗体效价高低与新生儿溶血病(HDN)的关系。方法:采用血型血清学方法,检测O型孕妇血清中IgG抗A(B)抗体效价。结果:407例O型孕妇中IgG抗A(B)抗体效价≥64的病例有285例,占70.02%,在O-A、O-B、O-AB各组合中,各血型组合均有发生HDN的可能(χ2=0.8437,P>0.05),且随着孕妇血清IgG抗A(B)抗体效价水平(<64、64～、128～、256～、≥512)的依次递增,HDN的发生率也越高。结论:新生儿ABO溶血病的发生率与抗体效价呈正比,当IgG抗A(B)抗体效价≥128时,新生儿ABO溶血病的发生率明显升高。
Objective: To investigate the relationship between serum anti-A (B) antibody titers and neonatal hemolytic disease (HDN) in type O pregnant women. Methods: Blood serum serological method was used to detect IgG anti-A (B) antibody titers in O-pregnant pregnant women. Results: There were 285 cases of IgG anti-A (B) antibody titers ≥64 in 407 O-pregnant women, accounting for 70.02%. In all the combinations of OA, OB and O-AB, (χ2 = 0.8437, P> 0.05). The incidence of HDN was also increased with the increase of serum IgG anti-A (B) antibody titer of pregnant women (<64,64,128,256 ~ The higher. Conclusion: The incidence of neonatal ABO hemolytic disease is proportional to the antibody titer. The incidence of neonatal ABO hemolytic disease is significantly increased when the titer of IgG anti-A (B) antibody is ≥128.