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目的探讨乳腺原发性T细胞淋巴瘤的临床病理特点、诊断及鉴别诊断。方法对1例双侧乳腺原发性T细胞淋巴瘤进行临床资料分析及光镜、免疫组化标记观察。结果①1例34岁女性患有原发性双侧乳腺恶性肿瘤。②组织学特点:瘤细胞呈片状及条索状排列,部分围血管分布,有明显嗜血管现象,瘤细胞胞质少,核小,深染有异型,部分核扭曲,染色质细,无淋巴上皮病变。③免疫组化染色:LCA、CD3、CD3均为阳性,而CD20、CD79a、CKLMW均为阴性。④随访:术后4个月死亡。结论乳腺原发性T细胞淋巴瘤是极为罕见的高度恶性肿瘤,其诊断主要依靠病理组织学及免疫组织化学标记。
Objective To investigate the clinicopathological characteristics, diagnosis and differential diagnosis of primary T-cell lymphoma in breast. Methods One case of primary breast T-cell lymphoma was analyzed by light microscope and immunohistochemistry. Results ① A 34-year-old female had primary bilateral breast cancer. ② histological features: tumor cells were flake and cord-like arrangement, part of the perivascular distribution, there are obvious bloodthirsty phenomena, tumor cells less cytoplasm, nuclear small, deep stained with abnormal, some nuclear distortions, fine chromatin, no Lymphoepithelial lesions. ③ immunohistochemical staining: LCA, CD3, CD3 were positive, and CD20, CD79a, CKLMW were negative. ④ follow-up: 4 months after the death. Conclusion Primary T-cell lymphoma is a very rare and highly malignant tumor whose diagnosis mainly depends on histopathology and immunohistochemistry.