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目的探讨纤溶酶原激活剂抑制物-1(plasminogen activator inhibitor-1,PAI-1)基因4G/5G多态性和早期妊娠子宫动脉舒张期切迹与复发性自然流产的关系,为早期诊断和治疗复发性自然流产提供依据。方法应用聚合酶链反应-限制性片段多态性(PCR-RFLP)分析,对61例反复自然流产患者(病例组)和52例正常妊娠对照组(对照组)做了PAI-1基因4G/5G多态性分析,并应用彩色多普勒超声检测子宫动脉舒张期切迹(uterine artery diastolic notches depth,ND)结果1.复发性自然流产组有ND切迹者占54.1%(33/61),正常妊娠对照组为34.62%(18/52),二者差异有显著性意义(χ2=4.30,P<0.05,OR值为2.23,95%CI 1.04-4.77。2.携带4G/4G基因型患者其子宫动脉血流循环阻力有增加趋势,(χ2=16.08,P<0.01,OR值为6.0,95%CI 2.38-15.12。结论1.子宫动脉血流循环阻力增加与复发性自然流产的发病有关联。2.PAI-1基因4G/4G型个体,同时有ND者自然流产的风险为对照组的4.25倍。
Objective To investigate the relationship between 4G / 5G polymorphism of plasminogen activator inhibitor-1 (PAI-1) gene and the diastolic notch of uterine artery in early pregnancy and recurrent spontaneous abortion And treatment of recurrent spontaneous abortion provide the basis. Methods Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis was performed in 61 patients with recurrent spontaneous abortion (case group) and 52 normal pregnancy control group (control group). PAI-1 gene 4G / 5G polymorphism and uterine artery diastolic notches depth (ND) were detected by color Doppler ultrasound.Results 1. There were 54.1% (33/61) of ND incisions in recurrent spontaneous abortion group, , The normal pregnancy control group was 34.62% (18/52), the difference was significant (χ2 = 4.30, P <0.05, OR was 2.23, 95% CI 1.04-4.77.2.) 4G / 4G genotype The uterine arterial blood flow resistance of the patients had an increasing tendency (χ2 = 16.08, P <0.01, OR = 6.0,95% CI 2.38-15.12) .Conclusions 1. The uterine arterial blood flow resistance increases and the incidence of recurrent spontaneous abortion Associated with .2PAI-1 gene 4G / 4G-type individuals, while the risk of ND spontaneous abortion of 4.25 times the control group.