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目的 :研究人体胃液内所带真菌是否具有还原硝酸盐的作用 ,从而探讨人类胃癌病因中 ,真菌因素的可能作用及作用机理。方法 :对正常 8例 ,浅表性胃炎 (CSG) 2 6例 ,萎缩性胃炎 (CAG) 2 2例 ,胃溃疡 (CU) 18例 ,胃癌 (GC) 19例 ,共 93份胃液进行真菌培养和pH值及硝酸盐、亚硝酸盐含量的测定 ,并对分离出的真菌进行了还原硝酸盐作用的实验。结果 :胃液真菌“污染”的情况较严重 ,不同的pH值范围内 ,胃液真菌培养的阳性率无明显差异 ,各种胃病患者的胃液内 ,真菌的阳性率与正常对照也无差异 ,但是具有还原硝酸盐作用的真菌的阳性率和胃液中亚硝酸盐的含量 ,GC组高于CSG组。结论 :胃内真菌可通过还原硝酸盐为亚硝酸盐而与胃癌有关
Objective: To study whether the fungus contained in gastric juice in human body has the effect of reducing nitrate, so as to explore the possible role and mechanism of fungal factors in the pathogenesis of human gastric cancer. Methods: Eight cases of normal, 26 cases of superficial gastritis (CSG), 22 cases of atrophic gastritis (CAG), 18 cases of gastric ulcer (CU), 19 cases of gastric cancer (GC), 93 cases of gastric juice for fungal culture And the determination of pH and nitrate and nitrite content, and the experiment of reducing nitrate in the isolated fungi. Results: Gastro-intestinal fungus “contamination” was more serious. There was no significant difference in the positive rate of gastric fluid fungal culture in different pH ranges. There was no difference in gastric juice and fungal positive rate between normal and stomach patients. The positive rate of nitrate-reducing fungi and nitrite content in gastric juice were higher in the GC group than in the CSG group. Conclusion : Gastric fungus can be related to gastric cancer by reducing nitrates to nitrite