论文部分内容阅读
本文研究大蒜、大蒜绿茶合剂对ＭＮＮＧ诱发大鼠胃癌及癌前病变过程中ＰＢＬ微核率的影响。结果显示，ＭＮＮＧ组（ＭＧ）ＭＮＦ在１０月与１６月时无明显差异，但较对照组（ＣＧ）始终显著增高（Ｐ＜０．００１），胃癌及癌前病变均高于ＣＧ（Ｐ＜０．００１），癌前病变明显低于胃癌（Ｐ＜０．００１），预防组（ＰＧ）、治疗１（ＴＧⅠ）与Ⅱ组（ＴＧⅡ）皆低于ＭＧ（Ｐ＜０．００１），ＰＧ在１６月较１０月时显著降低（Ｐ＜０．００１），与ＴＧⅠ无明显区别，而ＴＧⅡ较ＰＧ１０月时差异明显（Ｐ＜０．００５），但与ＰＧ１６月时和ＴＧⅡ无差异。证明ＭＮＮＧ的致突变、致癌变性可持续作用，大蒜、绿茶具有明显的抗突变、抗癌变效果，微核先于胃癌出现于癌前病变，从而检测ＰＢＬ微核可作为胃癌危险和早期的新标志。
This study was to investigate the effect of garlic and garlic green tea mixture on the micronuclear rate of PBL during gastric cancer and precancerous lesions induced by MNNG in rats. The results showed that MNF in the MNNG group (MG) had no significant difference between October and 16th, but was significantly higher than that of the control group (CG) (P<0.001). Gastric cancer and precancerous lesions were higher than CG (P< 0.001) Precancerous lesions were significantly lower than those of gastric cancer (P<0.001). Prevention group (PG), treatment 1 (TGI) and group II (TGII) were all lower than MG (P<0.001). PG It was significantly lower in 16 months than in October (P<0.001), and there was no significant difference from TGI, but TGII was significantly different from PG at 10 months (P<0.005), but there was no difference between PG16 and TGII. It is proved that the MNNG has a sustained and mutagenic and carcinogenic effect. Garlic and green tea have obvious anti-mutation and anti-cancer effects. Micronucleus precedes gastric cancer and occurs in precancerous lesions. Detection of PBL micronucleus can be used as a risk of gastric cancer and early new Sign.