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医生对付艾滋病,面临三重困难,需要:(1)预防感染和抑制病毒复制;(2)增强或恢复免疫系统及中枢神经系统;(3)治疗继发感染。目前既无治疗艾滋病的方法,亦无预防用的疫苗,本文综述在与艾滋病作斗争中发展药物和疫苗所可能采取的途径。药物为了发展有效的治疗艾滋病的方法,必需了解病毒是怎样复制的。HIV的构成是由一个RNA基因组被内核所围绕,最外层是包膜蛋白。为了进入宿主细胞,病毒先与T细胞膜上的一个受体结合,在细胞内吞作用后,
Doctors face HIV / AIDS and face triple difficulties. They need to: (1) prevent infection and inhibit viral replication; (2) enhance or restore the immune system and central nervous system; (3) treat secondary infections. There is currently neither a cure for AIDS nor a vaccine for prophylaxis. This article reviews possible avenues for the development of medicines and vaccines in the fight against AIDS. Drugs In order to develop effective ways of treating AIDS, it is important to understand how the virus replicates. The composition of HIV is surrounded by a core of the RNA genome and the outermost envelope protein. In order to enter the host cell, the virus first binds to a receptor on the T cell membrane and, after endocytosis in the cell,