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作者对14例357个牙周袋(深度在4 mm以上)的成年牙周病患者,进行了三个月的双盲研究。患者经彻底刮治和根面平整后,用15°钝针头和10ml注射器用0.2%洗必太作牙周袋冲洗。初诊后,病人回家自己冲洗,每天一次共四周。洗必太凝胶剂用无蜡牙线导入邻接牙面。同时给患者新牙刷一把,以及0.4%氟化亚锡牙膏或安慰剂牙膏用至试验结束。分别记录1、2、4、8和12周时的各种指数。试验期间不作口腔卫生指导。结果:试验组(洗必太+氟化亚锡),184个牙周单位,对照组(洗必太+安慰剂)173个牙周单位,其结果如下。菌斑指数(PLI):两组在4周时均有明显减少。试验组,在试验期间均有明显减少(P<0.001),以第4周达最高值(PLI平均减少0.8)。4周后PLI开始回升,但12周时仍低于基线值。对照组:4周后PLI开始回
The authors conducted a three-month, double-blind study of 14 patients with adult periodontal disease in 357 periodontal pockets (depths greater than 4 mm). Patients were thoroughly shaved and rooted flattened and rinsed with 0.2% chlorhexidine for a periodontal pocket using a 15 ° blunt needle and a 10 ml syringe. After the first visit, the patient rinse home, once a day for a total of four weeks. Wash must too gel with non-wax dental floss into the adjacent tooth surface. At the same time a new patient toothbrush, and 0.4% stannous fluoride toothpaste or placebo toothpaste until the end of the trial. Record various indices at 1, 2, 4, 8 and 12 weeks respectively. No oral hygiene guidance during the trial. Results: The experimental group (chlorhexidine + stannous fluoride), 184 periodontal units, the control group (chlorhexidine + placebo) 173 periodontal units, the results are as follows. Plaque index (PLI): Both groups were significantly reduced at 4 weeks. The test group, both during the test were significantly reduced (P <0.001), reaching the highest value in the fourth week (PLI average reduction of 0.8). PLI began to rise after 4 weeks but was still below baseline at 12 weeks. Control group: PLI began to be returned after 4 weeks