论文部分内容阅读
目的:了解近4年我院中成药引起的药品不良反应(ADRs)情况,为临床合理使用中成药提供参考。方法:对2009年1月-2012年12月由中成药引起的ADRs报告进行回顾性分析和评价。结果:131例有效报告中,18岁及以下未成年患者所占比例最高,占83.21%(109例);热毒宁注射液引起的ADRs最多,占60.31%(79例);中药注射剂静脉给药引发的ADRs位居第一,高达94.66%(124例);中成药或中西药联合用药71例,占54.20%;ADRs所涉及的皮肤及附件损害最为常见,达82.35%。结论:剂量过大、静脉给药、联合用药是我院ADRs的主要成因;严格按照药品说明书合理用药是防止或减少ADRs发生的关键。
Objective: To understand the adverse drug reactions (ADRs) caused by proprietary Chinese medicines in our hospital in recent 4 years and to provide references for clinical use of proprietary Chinese medicines. Methods: A retrospective analysis and evaluation of ADRs caused by proprietary Chinese medicines from January 2009 to December 2012 was conducted. Results: 131 cases of effective reports, the highest proportion of children under 18 years of age accounted for 83.21% (109 cases); Reisin injection caused the most ADRs, accounting for 60.31% (79 cases); Chinese medicine injection intravenous Drug-induced ADRs ranked the first, up to 94.66% (124 cases); Chinese patent medicine or western medicine combined 71 cases, accounting for 54.20%; ADRs involving the skin and accessories damage the most common, up to 82.35%. Conclusions: Overexposure, intravenous administration and combination therapy are the main causes of ADRs in our hospital. Rational use of drugs in strict accordance with the instructions of the drug is the key to prevent or reduce the occurrence of ADRs.