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卡介苗接种对总体生存率具有有益的非特异性作用。卡介苗接种后人体对结核菌素试验产生阳性反应并且有疤痕形成与提高生存数相关。在一项随机的现场研究中,初生低体重新生儿初生时接种卡介苗或延迟接种卡介苗。卡介苗的生产者测试了生长率相对较慢的时期制备的卡介苗。作者研究了卡介苗生产制备期间卡介苗的生长率与体内和体外诱导免疫应答之间的关联性。1 633名新生儿在初生时随机接种卡介苗,并在12个月龄时检查疤痕形成情况。在2和6月龄时
BCG vaccination has a beneficial non-specific effect on overall survival. After BCG vaccination, the human body produces a positive reaction to the tuberculin test and scar formation is associated with increased survival. In a randomized field study, newborns with low birth weight were vaccinated with BCG or deferred BCG at birth. Bacillus Calmette-Guérin (BCG) producers tested BCG prepared during periods of relatively slow growth. The authors studied the association between BCG growth rate and in vivo and in vitro induction of immune responses during BCG production. 1,633 newborns were randomized to BCG at birth and scars were examined at 12 months of age. At 2 and 6 months of age