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氯霉素是一种广谱抗菌素,适应证多,在细菌性感染疾病中广泛应用。临床使用中,又往往和其他药伍用,因此有可能产生合并用药后的相互作用。这种作用有的是有益的,可以伍用,但也有的是有害的或毒性反应,为配伍禁忌。因此,当临床使用氯霉素时,应注意以下伍用。氯霉素+口服抗凝剂:增强抗凝血作用2～4倍。因为氯霉素是药酶抑制剂之一,能抑制抗凝剂代谢的肝微粒体酶的活性,所以使抗凝剂半衰期延长,增加其有效血药浓度,同时
Chloramphenicol is a broad-spectrum antibiotic, indications and more, widely used in bacterial infections. In clinical use, it is often used in combination with other drugs, so it is possible to have an interaction after drug combination. Some of this effect is useful, can be used, but there are also some harmful or toxic reactions, incompatibility for compatibility. Therefore, when clinical use of chloramphenicol, should pay attention to the following use. Chloramphenicol + oral anticoagulant: to enhance the role of anticoagulant 2 to 4 times. Because chloramphenicol is one of the enzyme inhibitors, can inhibit the activity of hepatic microsomal enzymes metabolizing anticoagulants, so the anticoagulant half-life to extend and increase its effective plasma concentration, at the same time