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目的 探讨Lp(a)与脑卒中的关系及其遗传特性。 方法 采用ELISA双抗体夹心法检测 13个有脑卒中家族史家系成员的血清Lp(a) ,并比较已患者、Ⅰ、Ⅱ、Ⅲ级亲属与对照组的Lp(a)水平。 结果 13个家系成员中已患者Lp(a)水平高于对照组 ,Ⅰ级亲属中Lp(a)水平高于 30 0mg/L者明显多于对照组。以脑梗死为主要发病形式的家系中已患者及Ⅰ级亲属Lp(a)水平明显高于对照组。结论 有脑卒中家族史家系中Ⅰ级亲属Lp(a) >30 0mg/L者明显多于对照组 ,以脑梗死为主要发病形式的家系中Ⅰ级亲属Lp(a)明显高于对照组 ,有遗传倾向
Objective To investigate the relationship between Lp (a) and stroke and its genetic characteristics. Methods Serum Lp (a) levels in 13 pedigrees with family history of stroke were detected by sandwich enzyme - linked immunosorbent assay (ELISA). The levels of Lp (a) in patients with stage I, II, III relatives and controls were compared. Results The level of Lp (a) was higher in the 13 pedigrees than in the control group. The level of Lp (a) in the first degree relatives was significantly higher than that in the control group. The prevalence of Lp (a) in patients with first-degree relatives and their families with cerebral infarction as the main pathogenesis was significantly higher than that of the control group. CONCLUSIONS: Lp (a)> 30 0 mg / L in first-degree relatives of pedigrees with stroke family history is significantly more than that of control group. Lp (a) in first-degree relatives of pedigrees with cerebral infarction as the main pathogenesis is significantly higher than that of control group, Have a genetic predisposition